The AVE Challenge: Who is going to win the Nobel Sunday Night?
About 9 AM Stockholm time Monday, the Karolinska is going to wake up one to three biologists and announce they have won the Nobel Prize.
Thompson Reuters has their list based on citation, I call this hokey.
Here is Thompsons’s list with my thumb added in an appropriate direction where I think Reuters may be right or wrong. Then I added my own gueses. Finally, I have added some UW names I think may want to wait for the phone call.
Physiology or Medicine
C. David Allis
Tri-Institutional Professor and Joy and Jack Fishman Professor
Head, Laboratory of Chromatin Biology and Epigenetics
Rockefeller University
New York, New York, USA
-and-
Michael Grunstein
Distinguished Professor of Biological Chemistry
Geffen School of Medicine
University of California Los Angeles
Los Angeles, California, USA
For fundamental discoveries concerning histone modifications and their role in genetic regulation |
![thumbs down](http://handbill.us/wp-content/uploads/2011/09/thumbs-down.png)
Anthony “Tony” R. Hunter
American Cancer Society Professor
Molecular and Cell Biology Laboratory
Renato Dulbecco Chair
Salk Institute for Biological Studies
Adjunct Professor, Section of Molecular Biology
University of California, San Diego
La Jolla, California, USA
For the discovery of tyrosine phosphorylation and contributions to understanding protein kinases and their role in signal transduction
-and-
Anthony “Tony” J. Pawson
Distinguished Scientist and Apotex Chair in Molecular Oncology
Samuel Lunenfeld Research Institute of Mount Sinai Hospital
Professor in the Department of Molecular Genetics
University of Toronto
Toronto, Ontario, Canada
For identification of the phosphotyrosine binding SH2 domain and demonstrating its function in protein-protein interactions
comment: The tyrosine kinase receptor work was good, but a LOT mor people have been important beside these two.
|
Richard O. Hynes
Daniel K. Ludwig Professor for Cancer Research
David H. Koch Institute for Integrative Cancer Research
Massachusetts Institute of Technology
Howard Hughes Medical Institute Investigator
Cambridge, Massachusetts, USA
-and-
Erkki Ruoslahti
Distinguished Professor, Center for Nanomedicine
Sanford-Burnham Medical Research Institute
University of California Santa Barbara
Santa Barbara, California, USA
-and-
Masatoshi Takeichi
Director, RIKEN Center for Developmental Biology
Kobe, Japan
For pioneering discoveries of cell adhesion molecules, Hynes and Ruoslahti for integrins and Takeichi for cadherins
comment: This list is more reflctive of campaigning for the Nobel than for achievement.
Neither Hynes not Ruoslahti “disvoered” the integrins. Ruosalahti’s work with the RGD peptides is imortnat, but the perosn whose work was most seminal in understanding the integrins was Mark Ginsberg. who wrote the seminal papers on signalling.
Takeshi’s discovery of clacumependent adhesion molecules is a unique find, but others are responsible for the broadening of this to include whole classes of cadherins, identify their key roles in development, an cefine the beta catrenin signaling pathway.
Richard Hynes work is good, solif work on the integrins but he is only listed here because he conferred the name “integrin.”
From a UW point of view, John Harlan should have been included in any ist of adherance molecules since hid discovery of the first leukocyte adhesion molecule, a key discovery in inflammation. My wife was first author on that paper!
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And here is my list:
![](http://2.bp.blogspot.com/-NFMIOpApWX0/TnpcngHnM7I/AAAAAAAAB34/w975Dsqd8sU/s1600/thumb+rt.png)
- Shinya Yamanaka, Irv Weissman, Reudi Yaenish Tokyo, Gladstone, Stanford, MIT the stem cell
- Eric Lander, Phil Green MIT, Harvard, UW human genome project
- Ruslan Medzhitov Yale The innate immune system.
- Brian Druker, anti kinase therapy in cancer Oregon
These UW Names Deserve Nobels:
Earl Davies, blood coagulation
Phil Green, genome informatics
John Harlan, endothelial cell interactions with leukocytes
Jerry Nepom, immunology of type 1 diabetes
Lee Hood, Bob Waterston genome project
Arno Motulsky, Maynard Olsen, Mark Groudine not sure for what because they have done so much
Tags: Academic Standards, Academic Standards, Faculty, Foreign, Foreign Universities, Intellectual Property, Mission, Nobel, People, Ranking and Reputation, School of Medicine, Seattle Scene, UW, Washington State Higher Ed.
Posted 23 Sep 2011 by theaveeditor
in Schools & Colleges, Science