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THE Ave Challenge: Who will get the call from Stockholm next Sunday night.

 

THE-Ave.US Challenge: who is going to win the Nobel?

 

Next Sunday night (US time), about 9 AM Monday Stockholm time, the Karolinska is going to wake up one to three biologists and announce they have won the  Nobel Prize.

Thompson Reuters has their list based on citation, I call this hokey.

 I have added some UW names I think may want to wait for the phone call.

Thompsen Reuters:


PAIN

David Julius, for elucidating the molecular workings of how our nerves process the sensation of pain, opening the way to new advances in pain management,  This is c9ool science but I do not think the impact is broad enough across biology. .

 

 

Genetic Variation

Thompson selected three names : Charles Lee, Stephen W. Scherer and Michael H. Wigler .. for showing how variations in the genome other than the traditional mutations can cause disease.  I think these names are good, but there are too many others to consider.  If I were to pick one name, I would focus on someone doing the math that made all this possible ..Lander, Green or Pearl. (below)

 

Cell Adhesion

SMS: Hynes was not among the discovers of the integrins and his excellent work has not been unique. Ruosalahti is rumored to want the prize BUT his word on the peptide RGD has not yielded much clinical result. Personally, I would put Mark Ginsberg here, his work on what he called cytoadhesins was seminal to the huge world of integrin signalling. Tekeichi did discover the cadherins but a nobel for them surely would need to include a prize for the signalling pathways that use beta catenin. I would also include John Harlan since he, with my wife as first author, described the first adhesion molecule that controls inflammatory responses.

Richard O. Hynes
Daniel K. Ludwig Professor for Cancer Research, David O. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA USA; also Howard Hughes Medical Institute Investigator
Erkki Ruoslahti
Distinguished Professor, Center for Nanomedicine, Sanford-Burnham Medical Research Institute, La Jolla, CA USA

Cell Signaling and Control

SMS: I doubt this too,  There already have been prizes for the signalling pathways controlled by the tyrosine kinases as well as for the ligands that stimulate them.  The ony way I could see this is with Brian Druker.

Anthony “Tony” R. Hunter
American Cancer Society Professor, Molecular and Cell Biology Laboratory, and Renato Dulbecco Chair, Salk Institute for Biological Studies, and Adjunct Professor, Section of Molecular Biology, University of California San Diego, La Jolla, CA USA
Anthony “Tony” J. Pawson
Distinguished Scientist and Apotex Chair in Molecular Oncology, Samuel Lunenfeld Research Institute of Mount Sinai Hospital, and Professor, Department of Medical Genetics, University of Toronto, Toronto, Ontario, Canada

Genetic Regulation

SMS My only question here is whether Allis work is unque enough for a Nobel?  A LOT of folks have contributed to epigenetics, including the recent amazing discoveries that lamin s .. a nuclear “structural” protein determine inherited aging!
C. David Allis
Tri-Institutional Professor and Joy and Jack Fishman Professor, Head, Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, NY USA
Michael Grunstein
Distinguished Professor of Biological Chemistry, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA USA

And here is my list

 

UW Nobel is for UW faculty I think have a good chance.

UW Nobel

Mary Claire King, Breast cancer and interactions of the genes she found with modifying genes.

 

 

Reudi Jaenish, MIT,  Beatrice Mintz, Fox Chase,  the trangenic mouse.

 

 

 

UW Nobel

 

  • Eric Lander, Phil Green   MIT, Harvard, UW human genome project

Ruslan Medzhitov Yale The innate immune system. 

 

 Jerry Nepom, UW, Ake Lernmark Upsalla, the type 1 diabetes gene

 

 

 

 

  • Brian Druker, anti kinase therapy in cancer  Oregon (see comment about Tony Hunter above).

 

 

 

 

 

 

UW Nobel

Earl Davie, UW,  the coagulation cascade.

 

 

UW Nobel
Stan Fields, UW,  protein protein interaction map
                                   
More Names That Deserve Nobels
 

Phil Green, genome informatics
John Harlan, endothelial cell interactions with leukocytes
Bonney Ramsey, cystic fibrosis
Lee Hood, Bob Waterston   Maynard Olsen, genome project


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